Well, I can't think of any reason why sitting on a clustered server would have any impact on CR, as I have several CR installs on clustered servers. However, the only reason I adopt this architecture is because I have CE on these servers, and I like to have CR installed with CE for troubleshooting amongst other things.
If you don't have CE, I can't think of any point to having CR on a clustered server, being as the nature of the application is not to be active without user intervention, so installation on a client is usually the way to go.
Naith