We use cc:Mail R8 on our server. Our mail is routed through our ISP and then handled by our SMTP Gateway R8.31.00.5. When attempting to send mail out, the mail is bounced back giving the 452 error. I Watched the gateway and it seems to handshake with the ISP server and then immediately bounce the message back. Incoming messages are fine. I have plenty of room on my server. Is this a problem with the gateway or the ISP. Unfortunately I am unable to reach tech support at the ISP,so if someone could help I would greatly appreciate it.