I have been applying the changes on a server, then SP, then rebooting alltogether - in most cases that's enough. However, keep in mind the following: when you're talking about the "changes" - some of them will not complete until you reboot.<br><br>Now, here's the issue - you're applying the SP to change the system files to a different version. If the changes you do change all the files before reboot - you're cool. Otherwise - you might ran into problem if a simultaneous change attempted from your installed application(s) and SP.<br><br>BTW, not all of the changes require SP rerun - only the ones changing the system files/dlls - mainly new hardware/software installs, not regular maintenance or configuration changes.<br><br>Regards!