If your customer data already has location data (i.e. City) and this can be readily referenced against a region, then yes.
Supposing...
tblCUSTOMERS
CustID CustName CustTown
1 Jane Smith London
2 John Smith Bristol
3 Fred Bloggs Nottingham
4 Freda Bloggs London
5 Jane Doe Bristol
The following table can be created
tblREGIONS
Town Region
London South-East
Bristol South-West
Nottingham Central
Then...
1. Add column CustRegion to tblCUSTOMERS.
2. Execute the following SQL
UPDATE tblCUSTOMERS
SET tblCUSTOMERS.CustRegion = tblREGIONS.Region
FROM tblCUSTOMERS, tblREGIONS
WHERE (tblCustomers.CustTown = tblREGIONS.Town)