New to using Macola and havent gone live in the warehouse yet.

When and for what reason do you use Inventory Transaction Q = Quantity Adjustment?

I figure sometimes quantities are not what they are supposed to be and you need to change them with this transaction.  My question is...why would they be wrong?  I need to understand why and when this can occur, so anything you can find on this would be helpful.

If someone uses inventory without reporting this in Macola, then the inventory is wrong.  There are countless reasons why this could happen, regardless of what ERP package you are using.

Can you really not envision the physical count being different than the software?

Software Sales, Training, Implementation and Support for Macola, Synergy, and Crystal Reports.  Check out our Macola tools:
www.gainfocus.biz/exceladdin.html

You ask what can happen that inventory would not match...
(1) Your BOM issues the pieces X the qty per X scrap. If you run a higher % scrap your on hand inventory will be more than the actual on hand UNLESS someone is manually adjusting this.
(2) You have cartons that get damaged and are not able to use them to ship product. One or two, here and there, and no one thinks to have them ISSUED as scrap.
(3) The order is for 400 pieces of one part and the warehouse pulls and ships the wrong part. You don't know this until the customer calls, or you do a cycle count. Then both parts are do not match the Exact invt balance and have to be adjusted.

These are a few examples of what I have run into. I use "Q" to do these adjustments as well as cycle count adjustments.

Hope this is helpful.