Use the built in Replace VB function to replace any occurrence of one string or set of characters in a string with any other string or set of characters.
The syntax for the Replace function is:
Replace(string being manipulated, unwanted characters, alternative characters)
where unwanted characters are the characters (may only be one character, eg " or ') that you want to remove from your string, and alternative characters are the characters (again may only be one character, like a space) to be used in place of the unwanted characters.
So, if you have a variable, sString say, that holds the string He said, "Hello". and you want to replace the double quotes with single quotes, then you would use the following line:
sString = Replace(sString, Chr(34), Chr(39))
transforming sString to He said, 'Hello'.
Here Chr(34) is a double quote and Chr(39) is a single quote.